Guta Cola/ Pennywort Tincture
A small 2016 studyTrusted Source compared the effects of gotu kola extract and folic acid in boosting cognitive function after a stroke. This small study assessed the impact on three groups of participants — one taking 1,000 milligrams (mg) of gotu kola per day, one taking 750 mg of gotu kola per day, and one taking 3 mg of folic acid per day.
Although gotu kola and folic acid were equally beneficial in improving overall cognition, gotu kola was more effective in improving memory domain.
A separate studyTrusted Source looked at the cognitive enhancing effects of gotu kola water extract on mice. Although both young and old mice showed improvements in learning and memory using the Morris Water Maze, the effect was higher in the older mice.
How to use: Take 750 to 1,000 mg of gotu kola per day for up to 14 days at a time.
Gotu kola has the ability to enhance memory and nerve function, which gives it potential in treating Alzheimer’s disease. In fact, one 2012 study on mice found that gotu kola extract had a positive effect on behavioral abnormalities in mice with Alzheimer’s disease.
The extract was also shown, in lab and animal studies, to have a modest effect on protecting brain cells from toxicity. This could also protect the cells from forming the plaque associated with Alzheimer’s.
Still, further research is needed to determine exactly how gotu kola could be used to treat Alzheimer’s. If you’re interested in adding this to your treatment plan, talk to your doctor before use.
Researchers in an animal study from 2016Trusted Source found that gotu kola had an anti-anxiety effect on male mice that were sleep deprived for 72 hours. Sleep deprivation can cause anxiety, oxidative damage, and neuroinflammation.
Mice that were given gotu kola for five consecutive days before undergoing sleep deprivation experienced significantly less anxiety-like behavior. They also experienced improved locomotor activity and less oxidative damage.
A 2013 reviewTrusted Source of anti-anxiety herbal medicines also concluded that gotu kola has an acute anti-anxiety effect. However, more research is needed to confirm these findings.
How to use: Take 500 mg of gotu kola extract twice a day for up to 14 days at a time. You can take up to 2,000 mg per day in cases of extreme anxiety.
Gotu kola’s positive effect on brain function may also make it an effective antidepressant.
A review from 2016Trusted Source supports these findings, in part due to a study on 33 people with generalized anxiety disorder. The participants were asked to take gotu kola in place of their antidepressant medication for 60 days. They self-reported decreased stress, anxiety, and depression.
Another study discussed in the review assessed the effect of gotu kola on rats induced with chronic depression. The herbal remedy had a positive effect on certain elements of behavioral depression, including body weight, body temperature, and heart rate.
How to use: Take 500 mg of gotu kola twice a day for up to 14 days at a time. You can take up to 2,000 mg per day during times of intensified depression.